Various lysates were subjected to SDS PAGE followed by western blot with FNab01286(CASP12 antibody) at dilution of 1:1000
IP Result of anti-Caspase 12 (IP:FNab01286, 4ug; Detection:FNab01286 1:1000) with HEK-293 cells lysate 2000ug.
Immunohistochemistry of paraffin-embedded human prostate hyperplasia tissue slide using FNab01286(Caspase 12 Antibody) at dilution of 1:200
Background
Caspase 12 is an enzyme known as a cysteine protease. It belongs to a family of enzymes called caspases that cleave their substrates at C-terminal aspartic acid residues. It is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. Caspase-12 is located in the endoplasmic reticulum (ER). It is responsible for ER-stress-induced apoptosis, such as high calcium concentration, low oxygen and low glucose levels. This antibody detects endogenous levels of full-length caspase-12 protein (50 kDa) and its cleaved product (40-44 kDa).